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Hugo Kubinyi Phosphodiesterases and Their Inhibitors


Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

15874.73 RUR

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The Big Book of Sex Quotes : 1001 Quips and


Book Description"When authorities remind you of the sinfulness of sex, there is an important lesson to be learned. Do not have sex with the authorities."--Matt Groening (The Simpsons). Prudes beware: there are no repressive authoritiesor censors here. From Aphrodisiacs to Rude Food, Virginity to Viagra, these 1001 unexpurgated sex quotes--divided into 75 categories--are too good to keep under cover. As with every volume in the popular "Big Book" series, the seductive array of materialcovers a wide span, and nothing is too hot to handle. Some are fresh off the press: "Study Finds Sex-Pregnancy Link" trumpets one newspaper headline. (Who knew?) Others come from our finest comic geniuses, such as Woody Allen's "Sex without love is anempty experience, but as empty experiences go, it's one of the best." Whether it's Mae West's sassy "To err is human--but it feels divine" or Andy Warhol's surprising "Sex is the biggest nothing of all time," these are entertaining and amazing.

167 RUR

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Francoise Simon, Philip Kotler Building Global Biobrands. Taking Biotechnology to Market


From medicine and defense to food and cosmetics, biotechnological breakthroughs are creating huge new global market opportunities as well as unprecedented challenges. Companies from mega-pharmaceuticals to infotech giants and biotech start-ups must radically rethink their business models. In the first book on the business of biotechnology, Françoise Simon and Philip Kotler combine their biotechnology and marketing ex-pertise to show managers how to innovate with bionetworks, win customers with biobrands, and create sustainable advantage worldwide.Simon and Kotler explain in clear nontechnical prose how innovation in the new biosector will be driven by a web of cross-industry collaborations, and in particular by three transforming forces: information technology, consumerism, and systems biology. With timely industry cases, the authors demonstrate that by capitalizing on these forces, companies from Hitachi and Siemens to Amgen and Pfizer could become the biotech leaders of the coming decades.The chapters on building and sustaining biobrands are the centerpiece of this indispensable book. Simon and Kotler present a powerful framework that will enable any manager to redefine and transform traditional models into a new branding paradigm: the global "targeted" model as an alternative to the global "mass market" model. The authors illustrate how each of these models has proven successful in launching such blockbuster drugs as Viagra, Lipitor, Rituxan, and Gleevec.Re...

1685 RUR

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Fergus Shanahan Clinical Dilemmas in Inflammatory Bowel Disease. New Challenges


The second edition of Clinical Dilemmas in Inflammatory Bowel Disease: New Challenges, is a practical, up-to-date handbook providing expert guidance on specific clinical dilemmas and areas of difficulty that the gastroenterologist regularly faces in day-to-day practice. In this new edition, 75% of the “dilemmas” are brand new dilemmas facing the IBD specialist concerning emerging treatment therapies, such as the use of cannabinoids and Viagra for Crohn’s disease. The remaining 25% of the dilemmas are fully updated from the previous edition, incorporating the latest clinical thinking. Each of the 57 evidence-based chapters contains clear learning points, addresses different topics, and provides sound guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with IBD: established and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, specialist nurses, pharmacists, dieticians and counselors.

7253.86 RUR

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